https://www.3dsecret.eu/news daily 0.75 2025-09-30 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/df687ad4-dd21-40de-8c49-119e4f33448b/3DSECRET_GRAPHICS6.png https://www.3dsecret.eu/news/3dsecret-research-presented-at-advances-in-circulating-tumour-cells-2025 monthly 0.5 2025-09-30 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/dd98f67e-e93a-4e58-9d88-cae189d9cf57/Multime%CC%81dia.jpeg News - 3DSecret Research Presented at Advances in Circulating Tumour Cells 2025 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/inlers-showcase-3dsecret-technology-at-european-researchers-night-in-braga monthly 0.5 2025-09-30 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1759239003473-W5TBN7S2UR6RQW0I2S10/Image+%287%29.jpeg News - INLers showcase 3DSecret technology at European Researchers’ Night in Braga https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1759239003586-RDB2AC3UYC9RDSMBJZTF/Image+%288%29.jpeg News - INLers showcase 3DSecret technology at European Researchers’ Night in Braga https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1759239004930-B1DFOV5GMGAN3ECMHBYB/Image+%289%29.jpeg News - INLers showcase 3DSecret technology at European Researchers’ Night in Braga https://www.3dsecret.eu/news/e3n0l5dnjh0wpl8mpxx2kdl1vu7918 monthly 0.5 2025-09-30 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/3e35728b-2479-4c8d-b9c9-8d042ea94fe3/20250924_7_ENJIO__548_2.jpg News - Prize-Winning Cancer Research Presented at ENJIO 2024 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1c2a1423-7638-4a38-a563-efa9a8683ec5/20250924_7_ENJIO__544.jpg News - Prize-Winning Cancer Research Presented at ENJIO 2024 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/yc79nis6ycrucjb816452f5rzr81af monthly 0.5 2025-09-30 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/e7b2d0d4-57e8-49c9-8d4d-d65e07a239f0/undefined.jpeg News - INL Researcher Presents at FEMS EUROMAT 2025 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/synthetic-biomedical-data-precision-medicine monthly 0.5 2025-09-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1758895235358-ICSLVOKXUO5XYLAK6F3M/F1.large+%283%29.jpg News - Publication / Coherent Cross-modal Generation of Synthetic Biomedical Data to Advance Multimodal Precision Medicine - Make it stand out Qualitative comparison of real and generated data manifolds. UMAP projections of multimodal embeddings from the test set. The distribution of ground-truth data (Left) is compared with data reconstructed by the multi-condition model (Middle) and the Coherent Denoising ensemble (Right). Each point is a patient sample, colored by cancer type. Both generative approaches successfully capture the global topology and distinct cancer-type clustering of the original data. https://www.3dsecret.eu/news/plasmonic-nanostar-arrays-sers-sensing monthly 0.5 2025-09-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/94fa6a60-ecbb-463a-a9f9-4026a16165f2/adom70225-fig-0002-m.jpg News - Publication / Precision-Engineered Plasmonic Nanostar Arrays for High-Performance SERS Sensing - Make it stand out Lumerical simulation setup and results for nanodisk and asymmetric nanostar geometries. A). STL files of (left) nanodisk and (right) asymmetric nanostars to show the geometry of the features imported into Lumerical for simulation. B) Lumerical simulation area setup: (Left) diagram/top-down view of the 75 nm nanostars on a substrate with a 500 nm pitch distance. Grid square is 100 nm × 100 nm; (Right) 3D diagram of Lumerical setup, where the red region represents silicon, the grey region represents silicon oxide, the yellow stars represents gold, and the orange box outlines the FDTD simulation area. The white box indicates the source location. C) Simulation results showing electric field magnitudes for 50 nm nanodisks and 75 nm nanostars at different pitch spacings. D) Simulation results demonstrating local field magnitude at the sharp tips of nanostars of several sizes compared to nanodisks of 50 nm. https://www.3dsecret.eu/news/microfluidics-single-cell-cancer monthly 0.5 2025-09-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1758893521757-MFRP7BEUGJCKPZAD91F1/advs70728-fig-0001-m.jpg News - Publication / Advanced Microfluidics for Single Cell-Based Cancer Research - Make it stand out A) Models of cancer evolution. The linear model (on top) supports that each mutation is gradually superseded by the next, resulting in a single, dominant tumour clone. The branched model (on the bottom), where mutations extend and increase like the branches of a tree, demonstrates how different subclones evolve in parallel from a common ancestor, leading to intra-tumoral heterogeneity with various subclones coexisting within the tumour. B) Tumour heterogeneity, intravasation and extravasation. Schematic representation of intra-tumoral heterogeneity within the primary tumour, with various sub-clonal populations. It shows the steps of cancer dissemination, including the detachment of cancer cells from the primary tumour, intravasation into the bloodstream as circulating tumour cells (CTCs), and the subsequent extravasation of CTCs into distant tissues, leading to the formation of metastatic lesions. C) Comparison of bulk and single cell analyses. Bulk analyses provide an averaged molecular profile of the tumour, which can miss critical variations among cells. Single-cell analyses capture the diversity of individual cells, uncovering heterogeneous gene expression, detecting rare subpopulations, and offering detailed insights into the cellular architecture and functional states within the tumour https://www.3dsecret.eu/news/3dsecret-at-eacr-2025-congress monthly 0.5 2025-09-26 https://www.3dsecret.eu/news/3dsecret-project-meeting-cambridge-july-2025 monthly 0.5 2025-09-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/0570c572-7814-404e-8e28-c84c7e7f9258/1755163599977.jpeg News - 3DSecret Partners Meet in Cambridge for Third In-Person Meeting - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/3dsecret-at-inl-open-day-2025 monthly 0.5 2025-06-18 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1750247297507-MKT8RJIVM0098N02NQB2/OpenDay-350.jpg News - 3DSecret at INL Open Day 2025: Unlocking the Secrets of Cancer Cells with Microfluidics https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1750247296321-ROADKT43VNSUXT7QG179/OpenDay-359.jpg News - 3DSecret at INL Open Day 2025: Unlocking the Secrets of Cancer Cells with Microfluidics https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1750247303049-70IL9X72CS17U4YJZ9U8/OpenDay-448.jpg News - 3DSecret at INL Open Day 2025: Unlocking the Secrets of Cancer Cells with Microfluidics https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1750247304564-53UDDC8F7OBXCM2KNBJ2/OpenDay-449.jpg News - 3DSecret at INL Open Day 2025: Unlocking the Secrets of Cancer Cells with Microfluidics https://www.3dsecret.eu/news/advanced-science-review-tumour-heterogeneity-microfluidics monthly 0.5 2025-09-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/32316589-725a-49b8-8685-5e9c822369ed/1753089150692.jpeg News - New Review Article Published in Advanced Science - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/3dsecret-gordon-research-conference-microfluidics-2025 monthly 0.5 2025-09-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/abf4f7e1-e6c4-4105-bf7c-54816a11a452/image+%283%29.jpeg News - 3DSecret Project Highlighted at Gordon Research Conference on Microfluidics - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1758901526926-RCSGSCHWNZ8HC73XV7XI/image+%284%29.jpeg News - 3DSecret Project Highlighted at Gordon Research Conference on Microfluidics https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1758901520447-3EV23MQI0C6KVXBNTUN4/image+%282%29.jpeg News - 3DSecret Project Highlighted at Gordon Research Conference on Microfluidics https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1758901532590-U7J4TH3SMOHQIQOHJ7V7/image+%285%29.jpeg News - 3DSecret Project Highlighted at Gordon Research Conference on Microfluidics https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1758901531702-K3J7NHYYZRQICEZJQ2LN/image+%281%29.jpeg News - 3DSecret Project Highlighted at Gordon Research Conference on Microfluidics https://www.3dsecret.eu/news/synthetic-omics-generative-models monthly 0.5 2025-09-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1758894864571-CU8NDVAHZEVUVM90ESC5/F1.large+%282%29.jpg News - Publication / Toward Reliable Synthetic Omics: Statistical Distances for Generative Models Evaluation - Make it stand out Our proposed framework for the evaluation of generative models: Likelihood Test, Identity Test, and Training Progression measured with Energy Distance and Pointwise Empirical Distance. The plots show the results for a WGAN-GP trained on GTEx data. https://www.3dsecret.eu/news/single-cell-derived-spheroids-for-real-time-growth-and-metabolomic-studies-in-breast-cancer monthly 0.5 2025-09-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1758894467032-A504I2YUTV39PFKK303B/F1.large+%281%29.jpg News - Publication / Single cell-derived spheroids for real-time growth and metabolomic studies in breast cancer - Make it stand out Development of single cell-derived MCF-7 spheroids. A) Live/dead assay (Calcein-AM and BOBO-3) of MCF-7 cells cultured in 8-µL hydrogel domes (Matrigel or adECM at 5 or 10 mg/mL) for 14 or 28 days. Images were acquired using an LSM780 confocal microscope (magnification 20x). B) Spheroid diameters (µm) and live/dead ratio (%) of single cell-derived spheroids cultured in both matrices at concentrations of 5 and 10 mg/mL. Values show mean ± SD (N ≥ 14 spheroids from 3 independent experiments; *p < 0.05; **p < 0.01; **p < 0.001 with p-values obtained using a one-way analysis of variance (ANOVA) with Tukey’s post-hoc test for sample variables that followed a normal distribution (smaller-cell outlet) or a Kruskal–Wallis test followed by a Mann Whitney-U otherwise). (Scale bar: 100 µm). https://www.3dsecret.eu/news/inthenews-inl monthly 0.5 2025-01-21 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/f6f35ebe-237a-4c3a-bb07-e01a48e44515/Margarida-Esteves.jpg News - in the news/INL Website - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/inl-researcher-miguel-xavier-showcases-3dsecret-onnbsp90-segundos-de-cincia monthly 0.5 2024-12-20 https://www.3dsecret.eu/news/19j1f318gvvg2myb333l64kp06ggdd monthly 0.5 2025-09-30 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/47c8071a-d930-47c0-b171-bca5fc2111ac/Image+%286%29.jpeg News - Advancing Micro- and Nanoscale Biosciences: INL at NanoBioTech-Montreux - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/generative-models-validation monthly 0.5 2025-09-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1758894577162-LUTNT1Y0CFPOUQY9G3CQ/F1.large.jpg News - Publication / Generative Models Validation via Manifold Recapitulation Analysis - Make it stand out Lumerical simulation setup and results for nanodisk and asymmetric nanostar geometries. A). STL files of (left) nanodisk and (right) asymmetric nanostars to show the geometry of the features imported into Lumerical for simulation. B) Lumerical simulation area setup: (Left) diagram/top-down view of the 75 nm nanostars on a substrate with a 500 nm pitch distance. Grid square is 100 nm × 100 nm; (Right) 3D diagram of Lumerical setup, where the red region represents silicon, the grey region represents silicon oxide, the yellow stars represents gold, and the orange box outlines the FDTD simulation area. The white box indicates the source location. C) Simulation results showing electric field magnitudes for 50 nm nanodisks and 75 nm nanostars at different pitch spacings. D) Simulation results demonstrating local field magnitude at the sharp tips of nanostars of several sizes compared to nanodisks of 50 nm. https://www.3dsecret.eu/news/microtas2024-art-in-science monthly 0.5 2025-09-29 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/73224026-cf99-4149-b42b-f2a6708494d5/image+%288%29.png News - Science Meets Art: INL at MicroTAS 2024 Art in Science Contest - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1759149765572-CO70O0HFJGKZC30Z78A2/2b433af8-0c9e-47ce-8f38-ac9d954843f8+1.JPG News - Science Meets Art: INL at MicroTAS 2024 Art in Science Contest https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1759149773825-QXVZFOJXUDR8UTRU0SMK/IMG_5494+1.jpg News - Science Meets Art: INL at MicroTAS 2024 Art in Science Contest https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1759149772528-ERMITPTM3MHAUCH5E2YY/IMG_5514+1.jpg News - Science Meets Art: INL at MicroTAS 2024 Art in Science Contest https://www.3dsecret.eu/news/plasmonic-nanoparticle-sensors monthly 0.5 2025-09-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1758892811059-JKM8EEN6YT8I11TZH0CX/d4nh00226a-f2.gif News - Publication / Plasmonic nanoparticle sensors: current progress, challenges, and future prospects - Make it stand out Seed-mediated growth of plasmonic metal NPs. (a) Schematics of three representative types of nanoscale seeds (top) and the faceted NCs (bottom) produced from the seeds by seed-mediated growth. The red lines in the nanoscale seeds indicate twin boundaries and stacking faults.140,141 Reproduced from ref. 140 with permission from Wiley-VCH publisher, copyright 2009. (b) Schematics showing the overgrowth of homo- and hetero-structures with the faceted NPs as seeds. Metal nanorods are used as a representative example for controlling sizes and constructing core@shell and position-selective heterostructures. The illustrated plasmonic NPs are typically made of Au and Ag. https://www.3dsecret.eu/news/meet-the-partners-tecnalia monthly 0.5 2024-07-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1721993640782-5B52TXGT7K6XRHJ9YZFB/1704896605374.jpg News - Meet the Partners - Tecnalia - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/meet-the-partners-2cabraga monthly 0.5 2024-07-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/982ed1b4-f3de-4ef5-b14a-041bc94b6078/Enfermeiros+2CA.jpg News - Meet the Partners - 2CA Braga - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/meet-the-partners-fbk monthly 0.5 2024-07-08 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/6ed13136-4db4-405e-bcb6-5c8e1dd051d3/FBK.jpg News - Meet the Partners - Fondazione Bruno Kessler (FBK) - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/meet-the-partners-uvigo monthly 0.5 2024-06-03 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/9031b755-4415-437b-8a4a-e28c884db387/Uvigo.png News - Meet the Partners - Universidad de Vigo - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/3dsecret-outreach-2024 monthly 0.5 2025-09-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/7a156fcd-ed48-4d83-8ee2-5d2d2865642a/No+alternative+text+description+for+this+image+%281%29.png News - 3DSecret Project Highlighted at Pint of Science Portugal and UTAD Bioquímica Conference - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/meet-the-partners-sf monthly 0.5 2024-05-22 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/8885a7c0-8f16-4642-ac29-e80ecd4250a1/SF.jpg News - Meet the Partners - Sphere Fluidics - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/inthenews-nanowerk monthly 0.5 2025-01-21 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/81816e24-8da6-4aab-9cc4-ba8a9d296d69/Screenshot+2024-02-27+at+19.08.17.jpg News - in the news/nanowerk.com - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/3dsecret-eu-project-meeting monthly 0.5 2024-02-27 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/adf8922f-baa5-4338-9aed-da956a898a69/DSC_7360+%281%29.jpg News - 3DSecret EU project review meeting - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/meet-the-partners-inl monthly 0.5 2024-05-14 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/356468e2-8a39-4678-97e9-f490569dd527/3DSECRET.jpg News - Meet the Partners - INL - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/data-analytics-revolution-sers-clinic monthly 0.5 2025-09-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1758893793868-XQ60N6V7672H1EXKCQB2/1-s2.0-S0165993623003989-gr1_lrg.jpg News - Publication / Will data analytics revolution finally bring SERS to the clinic? - Make it stand out Optical properties of the skin can reduce incident light intensity. https://www.3dsecret.eu/news/3dsecret-sphere-bio-visit-microdroplet-technology monthly 0.5 2025-09-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/e13663a2-6014-4e97-ac1c-bb987cc861cf/1700224495966.jpeg News - Sphere Bio Visits INL to Share Advances in Microdroplet Technology - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/inl-miguel-xavier-total-nanosafe-conference-2025 monthly 0.5 2025-09-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/c733026c-a266-4811-b049-ee26cf2d55bc/1730990483017.jpeg News - INL Researcher Presents at Total Nanosafe Conference - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/3dsecret-sphere-bio-granta-park monthly 0.5 2025-09-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1581f3c0-2152-41d8-b06b-fd69fbe8274f/IMG_9523+1.JPG News - 3DSecret Represented at Sphere Bio’s New Facilities Inauguration - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/3dsecret-targets-metastasis-patterns-in-breast-cancer monthly 0.5 2023-10-23 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/1af3d3ff-e87d-4ae6-b7e2-fb854f93836e/Calcein_BOBO_2.png News - 3DSecret project, coordinated by INL, targets metastasis patterns in breast cancer - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/3e0bc250-da91-4f87-943f-d5a412015dcb/Lab1-1024x576.jpg News - 3DSecret project, coordinated by INL, targets metastasis patterns in breast cancer - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.3dsecret.eu/news/3dsecret-i3s-bioengineering-hub-2025 monthly 0.5 2025-09-26 https://images.squarespace-cdn.com/content/v1/63baa73110cae32a35457a95/376d37b1-fa20-4752-9bd2-60d7ea06c4f8/IMG_8040+1.JPG News - Advancing Microfluidics: INL at i3S BioEngineering Hub - Make it stand out Whatever it is, the way you tell your story online can make 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